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Appetite suppression typically begins around week 3 Average weight loss: 3-4% of starting weight Side effects are usually mild at lower starting doses Establishing hydration habits is critical during this phase Most users can eat normally with slightly smaller portions Proactive hydration habits established during month 1 pay dividends later

Cell culture was performed in 50 L or 250 L single-use bioreactors (SUBs)

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DOI: 10.1073/pnas.220418997 28

Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy